Inhibition of progression of aberrant crypt foci and colon tumor development by vitamin E
Shivapurkar N, Tang Z, Frost A, Alabaster O
Washington D.C., USA
Inhibition of progression of aberrant crypt foci and colon tumor development by vitamin E and beta-carotene in rats on a high-risk diet.
Cancer Letters 91, 125-132, 1995
Fische r-344 rats were fed a high-fat, low-fiber diet (HRD) for 2 weeks and were then given 2 subcutaneous injections of azoxymethane (AOM). After 6 weeks, rats were either maintained on the HRD (control) or crossed over to a HRD containing non-toxic levels of either Vitamin E, beta-carotene, folic acid or wheat bran. The dietary intervention was continued for 30 weeks. The results revealed that vitamin E and beta-carotene caused a significant decrease in the number of aberrant crypt foci (ACF) when compared to the effect of the HRD alone. The decrease in the number of ACF due to folic acid and wheat bran appeared to be much smaller. However, there was also a significant decrease in the incidence of colonic tumors and tumor multiplicity in both the vitamin E and beta-carotene groups that was not seen in the control group. The results clearly demonstrates the ability of vitamin E and beta-carotene to inhibit the growth of colonic ACF, even in the presence of the strong promoting effect of high levels of dietary fat, using a post-initiation experimental design.
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